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KMID : 0616120080390040352
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Korean Journal of Pharmacognosy
2008 Volume.39 No. 4 p.352 ~ p.356
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Single Oral Toxicity Study on the Standardized Extract of Salvia miltiorrhiza
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Chang Bo-Yoon
Oh Bo-Ram
Sohn Dong-Hwan
Kim Sung-Yeon
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Abstract
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Acute toxicity of standardized extract of Salvia miltiorrhiza Bunge was examined using male and female ICR mice. Mice were treated with standardized extract the intragastrically at 5 mg/kg, 50 mg/kg, 500 mg/kg or 2,000 mg/kg and observed for two weeks. At the doses used, no mortality or abnormal clinical signs in animals were shown during at the observation period. Also there was no difference in net body weight gain, gross pathological findings at the terminal sacrifice among the groups mice treated with different doses of the test substance. The results suggested that acute oral toxicity of standardized extract of S. miltiorrhiza in mice is very low at the conditions employed in this study.
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KEYWORD
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Standardized extract, Salvia miltiorrhiza, Acute oral toxicity
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